Two patients had intracranial hemorrhages during the study . Both occasions occurred during the washout period. A third individual had a past history of hepatitis C and diabetes mellitus, was found unconscious, and was hospitalized with coma and ketoacidosis. He died on the next hospital time from gastrointestinal hemorrhage. The loss of life occurred through the prophylaxis period, though it could not be motivated when the patient got received the last dose of AICC. Discussion Our study showed that all bleeding events, hemarthroses, and target-joint bleeding occasions were decreased during AICC prophylaxis significantly. On-demand treatment), and in this combined group, 38 percent of patients got no bleeding episodes during the prophylaxis period. A major challenge in the prospective trial design was achieving meaningful results in a comparatively little patient population statistically.In the Mexican cohort, there was complete protection against severe gastroenteritis after two prior infections; whereas in our cohort, after adjustment for possible confounders, the rate of protection was 79 percent after three prior infections . Although rotavirus was the one most common reason behind diarrhea and accounted for a higher proportion of serious cases of diarrheal disease than any various other cause, the rates of reinfection and asymptomatic infection were much higher than expected; just 30 percent of all identified infections were major, in comparison with 52 percent and 81 percent in Mexico and Guinea-Bissau, respectively, and just 30 percent of the primary infections were symptomatic .