Gregory Fontana.

Raj R. Makkar, M.D., Gregory Fontana, M.D., Hasan Jilaihawi, M.D., Tarun Chakravarty, M.D., Klaus F. Kofoed, M.D., D.M.Sc., Ole de Backer, M.D., Ph.D., Federico M. Asch, M.D., Carlos E. Ruiz, M.D., Niels T. Olsen, M.D., Ph.D., Alfredo Trento, M.D., John Friedman, M.D., Daniel Berman, M.D., Wen Cheng, M.D., Mohammad Kashif, M.D., Vladimir Jelnin, M.D., Chad A. Kliger, M.D., Hongfei Guo, Ph.D., Augusto D. Pichard, M.D., Neil J.We as a result favor an interpretation that acquisition of a TET2 mutation enhances the fitness of JAK2 single-mutant hematopoietic stem cells, whereas acquisition of a JAK2 mutation does not improve the fitness of TET2 single-mutant hematopoietic stem cells. Genotyping of the compartment of erythroid burst-forming systems from the same individuals revealed that in JAK2-first patients, the frequencies of single-mutant and double-mutant colonies for the reason that compartment resembled those seen in the hematopoietic-stem-and-progenitor-cell compartment . However, in TET2-first patients, double-mutant erythroid colonies were more frequent than TET2 single-mutant colonies , an outcome that contrasts with the genotype distribution in hematopoietic stem and progenitor cells.