Statistical evaluation was performed by using SAS software, version 9.2 , or R software program, version 2.13.1 is described in Fig. S1 in the Supplementary Appendix, obtainable with the full text of this content at NEJM.org. The 290 women who didn’t enroll did not change from those who enrolled regarding age significantly, race or ethnic group, insurance or approach to payment, or gestational age at delivery . Assessment of Microarray and Karyotype Analyses We compared the performances of karyotype and microarray analyses using samples obtained after delivery from 532 stillbirths where both karyotype and microarray assessment were attempted.Those who had adverse childhood encounters also had higher degrees of depression and higher concerns about illness and reported even more symptoms. Among sufferers whose symptoms could be explained by recognized physical disease, the average number of visits during 18 months was about the same for individuals who had and had not experienced childhood adversity . Childhood sexual misuse and parental neglect appeared to have the strongest effect on how often patients with unexplained symptoms visited doctors. The researchers claim that antidepressants, psychotherapy or cognitive-behavioral therapy may help patients with a history of childhood adversity, particularly if they have many medically unexplained symptoms and go to doctors frequently.