The relevant threshold has changed as time passes.

Tuberculosis was more regular in Africa, where in fact the disease remains endemic, whereas coronary disease and tumor were more regular in higher-income countries. The benefit of instant antiretroviral therapy across regions of the world indicates that controlling viral replication and improving immune function have broad positive effects. The primary end point incorporated serious positive and negative effects of antiretroviral therapy potentially, no safety concerns in the immediate-initiation group were identified. Grade 4 events and unscheduled hospitalizations happened more regularly than did the principal outcome, but rates of the events were related in both study groups. Immediate antiretroviral therapy benefited even those with a latest CD4+ count greater than 500 cells per cubic millimeter, which may indicate that a substantial part of the beneficial effect of immediate treatment is because of changes induced by antiretroviral therapy in markers apart from the CD4+ count.Aspirin has been proven to have limited advantage for those who have ankylosing spondylitis. Oral corticosteroids, such as prednisone , are not used for long-term treatment because of the high risk of side effects. Sulfasalazine and methotrexate work in some people with affected extremities with ankylosing spondylitis. Sulfasalazine is useful in individuals who have inflammatory bowel disease also. Individuals with AS are believed to produce excessive levels of the proteins tumor necrosis element . Medications that block TNF, such as for example infliximab and etanercept , are used to treat ankylosing spondylitis also.