Yoshiya Yamada.

Barker, M.D., Yoshiya Yamada, M.D., Jianda Yuan, M.D., Ph.D., Shigehisa Kitano, M.D., Ph.D., Zhenyu Mu, M.D., Teresa Rasalan, B.S., Matthew Adamow, B.S., Erika Ritter, B.S., Christine Sedrak, B.S., Achim A. Jungbluth, M.D., Ramon Chua, B.S., Arvin S. Yang, M.D., Ph.D., Ruth-Ann Roman, R.N., Samuel Rosner, Brenna Benson, James P. Allison, Ph.D., Alexander M. Lesokhin, M.D., Sacha Gnjatic, Ph.D., and Jedd D. Wolchok, M.D., Ph.D.: Short Statement: Immunologic Correlates of the Abscopal Impact in a Patient with Melanoma The abscopal effect refers to a rare phenomenon of tumor regression at a niche site distant from the principal site of radiotherapy.1 Localized radiotherapy has been shown to induce abscopal effects in several types of malignancy, including melanoma, lymphoma, and renal-cell carcinoma.2-4 The biologic characteristics underlying this effect are not completely understood, but it may be mediated by immunologic mechanisms.5 NY-ESO-1 can be an antigen expressed in 30 to 40 percent of individuals with advanced melanoma however, not present in normal adult cells except testicular germ cells and placenta.6 Ipilimumab has been shown to enhance immunity to NY-ESO-1, and patients with preexisting NY-ESO-1 antibodies have an increased likelihood of benefiting from ipilimumab.7 We describe a patient with metastatic melanoma in whom all of us measured adjustments in NY-ESO-1 titers before and through the observed abscopal effect.Type 2 diabetes, which is often but not always associated with obesity, affects about 95 % of individuals with diabetes. As the FDA noted, when untreated, type 2 diabetes can result in serious complications, including blindness, nerve and kidney damage, and heart disease. .

‘Agro’ mothers direct child’s behavior Researchers led by Steven R. Wilson of Purdue University videotaped forty mothers as they completed a ten minute play period with one of their children between the ages of three and eight years.